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American Society of Microbiology ABMM Sample Questions:

1. A research laboratory is studying the pathogenesis of respiratory syncytial virus (RSV) infection in infants.
They find that a specific viral surface glycoprotein is primarily responsible for attachment to host cells. This glycoprotein is:

A) Hemagglutinin (H)
B) Fusion protein (F)
C) Neuraminidase (N)
D) Matrix protein (M)

2. A patient with a history of recurrent fungal skin infections presents with a scaly, erythematous rash on their feet. Microscopic examination of skin scrapings treated with potassium hydroxide (KOH) reveals septate hyphae and arthroconidia. The MOST likely genus of the dermatophyte is:

A) Trichophyton
B) Aspergillus
C) Candida
D) Malassezia

3. A clinical microbiology laboratory is using PCR to detect the presence of the mecA gene in Staphylococcus aureus isolates. The mecA gene encodes for:

A) An efflux pump protein
B) Beta-lactamase enzyme
C) Altered penicillin-binding protein (PBP2a)
D) An aminoglycoside-modifying enzyme

4. A clinical microbiology laboratory is performing quality control on Gram stain reagents. A control slide containing Escherichia coli and Staphylococcus aureus shows both organisms staining purple after the complete staining procedure. The MOST likely cause of this error is:

A) Insufficient washing after crystal violet.
B) Omission of the iodine mordant.
C) Over-decolorization with alcohol-acetone.
D) Insufficient application of crystal violet.

5. A research team is investigating the host immune response to Mycobacterium tuberculosis. They discover that a specific mycobacterial glycolipid inhibits the maturation of phagosomes containing the bacteria, preventing their fusion with lysosomes. This mechanism allows M. tuberculosis to:

A) Induce the production of pro-inflammatory cytokines.
B) Survive and replicate within macrophages.
C) Evade detection by Toll-like receptors on macrophages.
D) Escape from the phagolysosome into the cytoplasm.

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